Publications

Endogenous and environmental factors that induce DNA replication defects and genomic instability in ER-negative heterozygous BRCA1 cells

Deshpande M, Paniza T, Brown R, Heslin K, Patel N, Madireddy A, Rosenwaks Z, Gerhardt J

EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection

Barreto-Galvez A, Niljikar M, Gagliardi JE, Guzman CP, Zhang R, Kumar V, Juwarwala A, Pradeep A, Saxena A, Montagna C, Mittal P, Gerhardt J, Xia B, Cao J, Kataoka K, Durbin AD, Qi J, Ye BH, Madireddy A

4EP300 Loss in Adult T-cell Leukemia: Finding the Therapeutic Window

Elevated Clonal Hematopoiesis in 9/11 First Responders Has Distinct Age-related Patterns and Relies on IL1RAP for Clonal Expansion

Verma D, Zeig-Owens R, Goldfarb DG, Kravets L, Pradhan K, Rockwell B, Sahu S, Kelly S, Giricz O, Jasra S, Zou Y, Prophete C, Torres LS, Aluri S, Chakraborty S, Kumari R, Gordon-Mitchell S, Wang J, Silver AJ, South TM, Olmstead SD, Hall CB, Sidoli S, Bender R, Landgren O, Greenberger LM, Wickrema A, Madireddy A, Shastri A, Pietras EM, LaFave LM, Nolan A, Cohen MD, Savona MR, Steidl U, Prezant DJ, Verma A

29/11 World Trade Center Exposure: From Dust to Leukemia

Polymerase Eta Recruits FANCD2 to Common Fragile Sites to Maintain Genome Stability

Niljikar M, Barreto-Galvez A, Patel S, Gagliardi JE, Kumar V, Pradeep A, Juwarwala A, Gerhardt J, Chang Y, Montagna C, Madireddy A

In revision.

5When a Fork Stalls: The Proteins That Protect Difficult DNA

Complex HPV-human DNA structures revealed by large-scale DNA analyses in an HPV-cancer derived cell line

Agosta EJ, Chang YC, Rao V, Hollingsworth J, Brown M, Kabiraj D, Einstein M, Van Arsdale A, Van Doorslaer K, Chan C, De S, Madireddy A, Haas BJ, Miller DE, Lenz J, Montagna C

In revision.

3How Viruses Maintain Themselves Inside Our Genomes

Dysregulation of the actin cytoskeleton and FMRP causes polar body protrusion defects in human fragile X premutation and aged oocytes

McCarter K, Deshpande M, Romanski P, Stratopoulou CA, Zaninovic N, Tareen M, Al-Mousawi R, James D, Madireddy A, Rosenwaks Z, Gerhardt J

In revision.

Visualizing DNA replication by single-molecule analysis of replicated DNA

Madireddy A, Gerhardt J

Editorial: Chromosomal fragile sites, genome instability and human diseases

Hu Q, Madireddy A, Gnan S, Chen CL

Temporal and structural patterns of hepatitis B virus integrations in hepatocellular carcinoma

Ren H, Chen X, Wang J, Chen Y, Hafiz A, Xiao Q, Fu S, Madireddy A, Li WV, Shi X, Cao J

3How Viruses Maintain Themselves Inside Our Genomes

Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair

Alvarez S, da Silva Almeida AC, Albero R, Biswas M, Barreto-Galvez A, Gunning TS, Shaikh A, Aparicio T, Wendorff A, Piovan E, Van Vlierberghe P, Gygi S, Gautier J, Madireddy A, Ferrando AA

5When a Fork Stalls: The Proteins That Protect Difficult DNA

High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster

Jasra S, Giricz O, Zeig-Owens R, Pradhan K, Goldfarb DG, Barreto-Galvez A, Silver AJ, Chen J, Sahu S, Gordon-Mitchell S, Choudhary GS, Aluri S, Bhagat TD, Shastri A, Bejan CA, Stockton SS, Spaulding TP, Thiruthuvanathan V, Goto H, Gerhardt J, Haider SH, Veerappan A, Bartenstein M, Nwankwo G, Landgren O, Weiden MD, Lekostaj J, Bender R, Fletcher F, Greenberger L, Ebert BL, Steidl U, Will B, Nolan A, Madireddy A, Savona MR, Prezant DJ, Verma A

29/11 World Trade Center Exposure: From Dust to Leukemia

Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells

Deshpande M, Paniza T, Jalloul N, Nanjangud G, Twarowski J, Koren A, Zaninovic N, Zhan Q, Chadalavada K, Malkova A, Khiabanian H, Madireddy A, Rosenwaks Z, Gerhardt J

Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites

Twayana S, Bacolla A, Barreto-Galvez A, De-Paula RB, Drosopoulos WC, Kosiyatrakul ST, Bouhassira EE, Tainer JA, Madireddy A, Schildkraut CL

5When a Fork Stalls: The Proteins That Protect Difficult DNA

BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage

Kang Z, Fu P, Alcivar AL, Fu H, Redon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky AK, Zou L, Shen Z, Aladjem MI, Xia B

Pluripotent stem cells with low differentiation potential contain incompletely reprogrammed DNA replication

Paniza T, Deshpande M, Wang N, O’Neil R, Zuccaro MV, Smith ME, Madireddy A, James D, Ecker J, Rosenwaks Z, Egli D, Gerhardt J

Replication Through Repetitive DNA Elements and Their Role in Human Diseases

Madireddy A, Gerhardt J

FANCD2 facilitates replication through common fragile sites

Madireddy A, Kosiyatrakul ST, Boisvert RA, Herrera-Moyano E, García-Rubio ML, Gerhardt J, Vuono EA, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL

1Dietary Azo Dye Toxicity: Mutagenesis & Carcinogenesis

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

Madireddy A, Purushothaman P, Loosbroock CP, Robertson ES, Schildkraut CL, Verma SC

3How Viruses Maintain Themselves Inside Our Genomes